Interests Areas

  • Health Care
  • ESG
  • Urban Planning

Projects

PINN for ECG Signal Denoising

PINN for ECG Signal Denoising

In this study, we propose EAND-ARN, a novel Electrophysiology-Aware Adaptive ResNet enhanced by numerical differentiation to address the inverse ECG problem.
ECG imaging (ECGI) aims to non-invasively reconstruct heart surface potentials (HSP) from body surface potentials (BSPM), but the ill-posed nature of the problem makes it highly sensitive to measurement noise.

Our key contributions include:

  • Numerical Differentiation for EP Constraints
    Unlike automatic differentiation (AD), our approach explicitly computes spatial Laplacian and temporal derivatives, effectively incorporating electrophysiological (EP) priors to improve stability and accuracy.
  • Adaptive Residual Network (ARN)
    We introduce trainable residual connections to optimize gradient flow, enabling deeper networks and mitigating initialization issues.

Results & Impact:

Extensive experiments show that EAND-ARN outperforms traditional methods (e.g., Tikhonov regularization, STRE, and prior deep learning models) across multiple noise levels. Our model achieves

Lower Relative Error (RE)
Lower Mean Squared Error (MSE)
Higher Correlation (CC)

Particularly in complex cardiac regions, these findings demonstrate the clinical potential of EAND-ARN, offering a more reliable computational tool for cardiac electrophysiology research and arrhythmia diagnosis.

fMRI-fNIRS

Functional near-infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) are both neuroimaging techniques that measure changes in brain blood oxygenation fNIRS is more portable and cost-effective than fMRI, but inferior spatial resolution and penetration depth Applications: studying brain function in naturalistic environments, developmental and clinical populations, infants and toddlers